Therapeutic System 1.0
1. Optimize diet: minimize simple carbohydrates (read white sugar and high-fructose corn syrup), minimize inflammation – there are various low glycemic, low inflammatory, low grain diets that are used depending on individual circumstance. The aim in each case is to maximize insulin sensitivity and minimize inflammation. IgG Food Antibody testing can be helpful to identify potentially inflammatory responses to foods.
2. Enhance autophagy (housecleaning of wastes/dead cells), trigger ketogenesis by fasting for 12 hours each night, including 3 hours prior to bedtime. This reduces insulin & beta-amyloid plaque buildup.
3. Reduce stress – with yoga, meditation, music, relaxation apps. This aims to reduce inappropriately high cortisol. Prolonged high cortisol shrinks your hippocampus, crucial for memory. Heart-rate Variability (HRV) testing can help assess how you are coping with stress.
4. Optimize sleep – 8 hours a night, with 1-3 mg of melatonin at night, tryptophan 500 mg 3X per week, rule out/treat sleep apnea, attend to sleep hygiene (avoid light exposure in the evening, keep a regular sleep schedule).
5. Exercise – 30-60 minutes per day, 4-6 days/wk. Weight training is critically important.
6. Scientifically-validated brain training e.g BrainHQ & other brain stimulation (reading, playing a musical instrument, word puzzles)
7. Drop Homocysteine below 7, with Methylcobalamin, MTHF (methylenetetrahydrofolate), P5P (pyridoxal-5-phosphate), TMG (trimethylglycine) if necessary. Know your methylation genetics
8. Maintain serum B12 > 500, with Methylcobalamin.
9. Keep hs-CRP < 1, Albumin/Globulin > 1.5 with an anti-inflammatory diet and supplement: curcumin, DHA/EPA, measure your fatty acid profile e.g. OmegaQuant dried blood spot profile
10. Optimize fasting insulin < 7 and HbA1C < 5.5 via diet guided by consultation with Lifestyle Coach
11. Optimize hormone balance via serum and urine testing and bioidentical hormone replacement as needed: Free T3, Free T4, TSH, Pregnenolone, Progesterone, Estradiol, Testosterone, Cortisol & DHEA
12. Maintain GI health, address leaky gut/leaky brain – with probiotics and prebiotics if necessary, specialized testing of GI function and IgG Food Antibody testing
13. Reduce beta-amyloid levels: supplementation with Curcumin, Ashwaganda
14. Supplement to promote cognitive enhancement: Bacopa monniera, magnesium threonate
15. Supplement Vitamin D3 and Vitamin K2: with Vitamin D3 dosing guided by serum testing
16. Increase Nerve Growth Factor (NGF): Lion’s Mane (H. erinaceus ), acetyl-l-carnitine, low-dose Lithium orotate
17. Provide building blocks to rebuild synapses: DHA, citicoline
18. Optimize antioxidants: supplement mixed tocopherols & tocotrienols, Selenium, blueberries, n-acetylcysteine, ascorbate, alpha-lipoic acid.
19. Optimize Zn: free Cu ratio guided by serum testing and judicious supplementation with zinc and copper
20. Measure fatty acids guided by testing: OmegaQuant dried bloodspot test supplement DHA for structure, EPA for function
21. Optimize mitochondrial function: CoQ10 or ubiquinol, alpha-lipoic acid, polyquinoline quinine (PQQ), n-acetylcysteine , ALCAR (acetyl-L-carnitine), Se, Zn, resveratrol, ascorbate, thiamine
22. Increase focus/increase acetylcholine synthesis: pantothenic acid
23. Increase Sirtuin enzyme function: resveratrol
24. Identify toxicity: evaluate toxic element burden (lead. Mercury, cadmium, aluminum)typically done by urine testing and detoxify/remove as necessary. Some people are very sensitive to EMF (wifi, cell towers, etc), screen for mold toxins and other environmental toxins. Detoxify as needed
25. Medium chain triglycerides: coconut oil as an alternate brain fuel
26. Assess genetic factors such as ApoE3/E4 status that can contribute to Alzheimer’s Disease via DNA testing
27. Supplement to reduce cortisol: phosphatidyl serine, phellodendron